Abstract
The crude ethanol extract from the leaves of Dendropanax cf. querceti (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, and H-4IIE tumor cell lines. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the triterpene lupeol. The mechanism of cytotoxic activity of lupeol has been determined to be inhibition of topoisomerase II.
Publication types
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Letter
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Humans
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Pentacyclic Triterpenes
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Plant Extracts / pharmacology*
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Plant Leaves / chemistry*
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Plants, Medicinal / chemistry
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Rats
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Pentacyclic Triterpenes
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Plant Extracts
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Triterpenes
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lupeol